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Smoothened Agonist (SAG)

CAS No. 912545-86-9

Smoothened Agonist (SAG)( Smoothened Agonist )

Catalog No. M16550 CAS No. 912545-86-9

SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Smoothened Agonist (SAG)
  • Note
    Research use only, not for human use.
  • Brief Description
    SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM).
  • Description
    SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM).
  • In Vitro
    ——
  • In Vivo
    Animal Model:Pregnant C57BL/6J mice Dosage:15, 17, 20 mg/kg Administration:A single i.p.Result:Effective in ca. 80% of the embryos and increased Gli1 and Gli2 mRNA expression in the limb bud, with Gli1 mRNA being the most upregulated at the dose of 20 mg/kg.
  • Synonyms
    Smoothened Agonist
  • Pathway
    GPCR/G Protein
  • Target
    Hedgehog (Hh)
  • Recptor
    Smoothened
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    912545-86-9
  • Formula Weight
    490.06
  • Molecular Formula
    C28H28ClN3OS
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 40 mg/mL warmed (75.97 mM); Water: 100 mg/mL (189.92 mM); DMSO: 71 mg/mL warmed (134.84 mM)
  • SMILES
    CNC1CCC(CC1)N(CC1=CC=CC(=C1)C1=CC=NC=C1)C(=O)C1=C(Cl)C2=CC=CC=C2S1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chen JK, et al. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6.
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